Obstetrics and Pediatrics Research

This page was updated on 04-02-2020.

  • Among 149,082 reported cases of COVID-19 cases in the United States, 2572 (1.7%) were among children <18yo
  • Common signs of fever, cough, or shortness of breath were reported less frequently in children (73% of the time) than adults (93% of adults reported at least one of these symptoms)
  • An estimated 5.7% of pediatric COVID-19 cases were reported to be hospitalized, with children <1 year accounting for the majority of these hospitalizations
  • 23% of pediatric COVID-19 patients had pre-existing conditions such as chronic lung disease like asthma, cardiovascular disease, or immunosuppression
  • Three deaths were reported among pediatric cases, though it is not certain whether COVID-19 was the cause of death 
  • Full article can be found here.
  • Of 72,000 total COVID-19 cases from China, 1.2% were in patients aged 10-19 years, 0.9% in patients <10 years, however lower rates may be associated with less exposure to the virus
  • 1 death was reported in an adolescent, and no deaths were reported in children ages 0-10
  • Clinical manifestations are similar in children as adults: fever, fatigue, dry cough, respiratory distress
  • Transmission in children is the same as in adults, and there are reported asymptomatic cases (1 child with no symptoms but a high viral load)
  • In one small study from China, 7/20 pediatric patients infected with COVID-19 had a pre-existing condition 
  • Children should avoid seeking non-urgent in-person medical care to limit their risk of exposure, which requires increased access and availability of telehealth visits
  • An essential role of the pediatrician during this pandemic is to advocate for children whose basic needs may not be met as a result of school closures, including nutrition and mental health services
  • Full article can be found here.
  • Out of thirty-three neonates born to mothers infected with COVID-19, three tested positive for the virus.
  • The most common symptom was shortness of breath.
  • There were no deaths, and all three infants had negative SARS-CoV-2 swabs by day 7 of life.
  • Though previous studies had not detected virus in cord blood, amniotic fluid, or breast milk, this study suggests it cannot be ruled out that there is vertical transmission of the virus from mother to baby.
  • Full article can be found here. 
  • Neonate born to a mother with confirmed COVID-19 (presented at 34 weeks gestation) was found to have elevated antibodies to SARS-CoV-2 and elevated cytokines (includes IL-6, IL-10) 2 hours after birth
  • All nasopharyngeal PCR swabs taken from 2 hours old to 16 days of age were negative
  • Elevated IgM level 2 hours after delivery suggests the neonate was infected in utero
  • Full article can be found here
  • Retrospective cohort analysis of 6 pregnant women with confirmed COVID-19
  • All had cesarean deliveries during 3rd trimester in negative pressure isolation rooms with mothers wearing masks; infants immediately isolated post delivery. 
  • SARS-CoV-2 was not detected in the serum or throat swab by RT-PCR in any of the newborns. All 6 infants were asymptomatic, but had virus-specific Ab’s detected in their serum (IgG detected in 5, IgM detected in 2).
  • Virus-specific IgM was detected in 2 infants at time of birth, which could have been produced by the infant if the virus crossed the placenta
  • Full article can be found here
  •  Between January 17th and March 1st, 2020, 661 COVID-19 cases were reported in Ningbo and Wenzhou cities in China, and 36 were children age 1-16 years.
  • No severe or critically ill cases were seen.
  • All patients recovered after 14 days.
  • Full article can be found here.
  • Observational study of 171 children < 16 years old admitted to Wuhan Children’s Hospital from January 28 to February 26, 2020 with confirmed SARS-CoV-2 infection
  • Common clinical characteristics: fever (41.5%), cough (48.5%), and pharyngeal erythema (46.2%). The most common radiologic finding was bilateral ground-glass opacity (32.7%).
  • 27 patients (15.8%) were asymptomatic and had no radiologic features of pneumonia.
  • 3 patients required ICU and vents; all had coexisting conditions (hydronephrosis, leukemia, and intussusception).
  • A 10-month-old child with intussusception had multiorgan failure and died 4 weeks after admission
  • SARS-CoV-2 causes a spectrum of illness in children, with majority causing mild or asymptomatic illness in children less than 16 years old
  • Full article can be found here
  •  Retrospective analysis of 2,143 pediatric patients < 18 years old with confirmed or suspected COVID-19 in China from January 16 to February 8, 2020
  • ~94% of cases were considered asymptomatic, mild, or moderate
  • Patients less than 1 years old had more severe or critical illness (10.6%), consisting of hypoxia, dyspnea, central cyanosis, ARDS, respiratory failure, or multiorgan dysfunction
  • 1 patient (14yo) had died at time of analysis 
  • Full pre-publication release can be found here.